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Crop Resistance to Nematodes by Disrupting Host Plant Receptors of Cyst Nematode Secreted CLE Peptides

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*Abstract

Crop Resistance to NematodesParasitic nematodes that attack the roots of plants are estimated to cause an annual worldwide crop damage of over $100 billion. For soybean, the most important pathogen is the nematode Heterodera glycines, which in the US causes an annual loss of more than 120 million bushel valued at over $1.2 billion. Other Heterodera species can cause significant damage to corn, while potato nematodes of the Globodera genus can result in up to 60% reduction in potato yield. Crops resistant to nematodes are therefore of great economic interest.The current invention developed by researchers at the University of Missouri is a genetic approach to make plants resistant to infestation from cyst nematodes attacking soybean, corn and potato. The nematodes secrete effector proteins in order to connect with the plant’s root cells, and plants lacking the receptors these effector proteins interact with have increased nematode resistance. Disruption of the plant receptors did not result in obvious changes to root growth in the plant and can be employed to develop a novel management tactic to reduce cyst nematode parasitism of crop plants. POTENTIAL AREAS OF APPLICATIONS- Nematode resistant crops of soybean, corn and potato MAIN ADVANTAGES OF INVENTION- Genetically modified plants- Normal root phenotype- Increased crop yields- Decreased use of pesticidesSTATE OF DEVELOPMENTPartial resistance has been achieved in the model organism Arabidopsis thaliana and strategies for improving the resistance are being researched. Nematode resistant soybean and potato are under development. LICENSING POTENTIALUniversity seeks licensee with potential to commercializePATENT STATUS: Patent application submittedTECHNOLOGY INNOVATORSMelissa G Mitchum, Amy Replogle, Jianying Wang, Xiaohong Wang, Shiyan Chen, Ping Lang, Eric L Davis, Thomas J Baum, Richard S HusseyTECHNOLOGY MANAGER CONTACTSamuel E. Bish, PhD; bishs@missouri.edu; 573-882-5016.

*Principal Investigation

Name: Melissa Mitchum, Assistant Professor, Div of Plant Sciences

Department:

Name: Amy Replogle, Graduate Research Assistant

Department:

Name: Jianying Wang, Research Associate

Department:

Name: Xiaohong Wang, Professor Assistant Courtesy

Department:

Name: Shiyan Chen, Research Assistant

Department:

Name: Ping Lang, Research Associate

Department:

Name: Eric Davis, Williams Neals Reynolds Distinguished Professor and Director of Graduate Program

Department:

Name: Thomas Baum, Professor and Chair

Department:

Name: Richard Hussey, Distinguished Research Professor

Department:

其他

国家/地区

美国