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Chitosan-based Hydrogels with Improved Properties

总结

OSU researchers have developed a multi-layered injectable tissuescaffold (hydrogel) which can be used as a regeneration platform for defective tissuessuch as cartilage in the knee. This hydrogel could be used in conjunction withmicrofracture surgery, or be a stand-alone procedure reducing the need forinvasive surgeries. This multi-layered gel is anisotropic in nature, and mimicsthe four zones of native cartilage tissue. By recreating the native environmentof cartilage tissues, cells seeded within the hydrogel should be driven to performthe appropriate cellular functions. The end result of using this hydrogel isthat engineered tissue will closely mimic native cartilage that will possessthe ability to resist deterioration over the long run. Furthermore, the optionof a minimally invasive procedure may lead to less pain, decreased recoverytime and better motion due to less scar tissue formation.  This hydrogel also has the potential to beused in multiple tissue types including bone, cartilage, heart, and spinaltissues, as well as blood vessels.

技术优势

·       Low cost·       Minimally-invasive optionthat is compatible with current repair options·       Potentially lowers the riskof infection and pain to the patient·       Anisotropic gel mimicsnative cartilage tissue

技术应用

·       Cartilagerepair·       Bone, bloodvessel, spinal and Cardiac muscle tissue repair

详细技术说明

None

*Abstract

None

*Background

Millions of cartilage injuries occur each year through physicaltrauma or excessive wear and tear. Twenty-to-sixty percent of kneearthroscopies reveal some focal chondral or osteochondral defects. Cartilagehas minimal healing potential due to the absence of vascularity and failure ofchondrocytes to migrate and replicate. Moreover, this damage may progress toarthritis, eventually leading to total knee replacements, a highly invasive,costly surgery, which requires an extended recovery period. Two of the mostcommon treatments for cartilage damage, microfracture surgery and AutologousChondrocyte Implantation (ACI), are invasive surgeries that attempt to restorecartilage tissue. Unfortunately, cartilage generated with these methods lacksnative hyaline characteristics, leading to deterioration of the repair tissueand extremely modest long-term outcomes. Cartilage repair treatments wouldbenefit greatly from a minimally invasive approach that generates native-likehyaline cartilage tissue that will resist deterioration over long-term.

*Stage of Development

A prototype is available and biocompatibilityhas been tested in mice.

国家/地区

美国