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Treatment of obesity through the inhibition of CaMKII

总结

During nutrient deprivation, the liver produces glucose through a process known as hepatic glucose production (HGP). Excessive glucose production via HGP is thought to play a role in the high blood glucose levels observed in patients suffering from obesity and type II diabetes. The enzyme CaMKII, which has previously been linked to Alzheimer’s disease and heart arrhythmia, has been shown to play a role in the signaling pathway that causes HGP. This technology provides a method to treat obesity and related metabolic disorders by reducing the activity of CaMKII, and consequently, HGP and blood glucose levels.

技术优势

Unique therapeutic target that is distinct from currently marketed medicationsCan be used in addition to other obesity and diabetic treatmentsWell characterized animal models Patent Information:Patent Pending (US 20140314789)Tech Ventures Reference: IR CU12060

技术应用

Development of drugs that inhibit CaMKII to treat obesity and associated metabolic disorders (e.g. type II diabetes)Target for treatment of heart arrhythmiasWeight loss supplement in addition to diet and exercise

详细技术说明

None

*Abstract

None

*Inquiry

Joan MartinezColumbia Technology VenturesTel: (212) 854-8444Email: TechTransfer@columbia.edu

*IR

CU12060

*Principal Investigation

*Publications

Ozcan L, Wong CCL, Li G, Xu T, Pajvani U, Park SKR, Wronska A, Chen BX, Marks AR, Fukamizu A, Backs J, Singer HA, Yates JR III, Accili D, Tabas I, “Calcium Signaling through CaMKII Regulates Hepatic Glucose Production in Fasting and Obesity” Cell Metabolism. 2012 May 2;15(5):739-751.

国家/地区

美国