ABCA1 PEST domain-related compositions and methods
Lead Inventors: Nan Wang Isolated ABCA1 protein having a mutation within its PEST domain, related nucleic acids, vectors, host cells, pharmaceutical compositions and articles of manufacture are described.A method for increasing the formation of HDL in a subject comprising administering to the subject an agent that inhibits the PEST-mediated proteolysis of ABCA1 protein in the subject's cells is described. An article of manufacture comprises a packaging and a pharmaceutical agent.The methods can be used for determining whether a protease inhibitor increases the rate of cholesterol efflux from a cell and for increasing ABCA1-mediated cholesterol efflux from a cell and for increasing HDL formation in a subject, thereby treating atherosclerosis in a subject.
Isolated ABCA1 protein having a mutation within its PEST domain, related nucleic acids, vectors, host cells, pharmaceutical compositions and articles of manufacture are described.A method for increasing the formation of HDL in a subject compris...
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