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Efficient Collection of Separated Biomolecular Portions from Gel Samples

技术优势

Efficientway to collect separated biomolecular portionsAbilityto be used with small sample sizesHighcollection efficiencySuitablesamples include, but are not limited to, DNA or RNA

详细技术说明

A device and methods for the efficientcollection of separated biomolecular portions from gel samples.

*Abstract

This technology employs a three-dimensionalseparation strategy that allows for efficient and reproducible results.  Suitable biomolecular samples include, butare not limited to, DNA or RNA.

*Background

The traditional method ofbiomolecular portion separation using gels is very well established, and is thepreferred method in the field; however, the problem with this method is thatbiomolecular portion extraction from the gel is an inefficient process with themajority of the separated fraction being lost in the process. One promisingmethod utilizes a “lab on a chip,” where a silicon wafer or other substrateincludes channels or other physical features that enable manipulation ofsolution(s) and nucleic acid samples. Lab-on-a-Chip (LOC) technology isa rapidly expanding area of science. It has applications in biotechnology,medicine, clinical diagnostics, chemical engineering, and pharmaceutics. Still, there is a pressing needto develop a novel method to extract and fractionate nucleic acids and theirprotein complexes, which is compatible with very small sample amounts and has highcollection efficiency of the separated portions.

国家/地区

美国