A Full-length cDNA Infectious Clone of Emerging Porcine Senecavirus A
Description: Researchersat Kansas State University have created full-lengthcDNA infectious clones of Seneca Valley Virus that can be used as an importantresearch tool for viral pathogenesis studies, as well as used as a viralbackbone for modified live virus (MLV) vaccine development.Senecavirus A (SVA), formally named as Seneca Valley Virus (SVV), is asmall, non-enveloped picornavirus. This virus was unknown until 2002 when itwas discovered as a tissue culture contaminant. The pathogenicity of SVA inswine and other animals is unclear, but its recent presence is associated withoutbreaks of idiopathic vesicular disease in swine. The clinical signs ofidiopathic vesicular disease are indistinguishable from those of swinevesicular disease virus, vesicularstomatitis virus, vesicular exanthema of swine virus, and foot and mouthdisease virus. Because any vesicular disease must be reported and investigatedas a potential foreign animal disease, the development of control measuresspecific for SVA is critical. Advantages: Traditional method for MLVvaccine development is to serially passage the virus through cell culture.Mutations introduced into the virus during the viral passage are random, andcell culture attenuation process takes a long period of time. In contrast, using full-length cDNA infectious clones with reversegenetics technology, we can generate recombinant viruses with targetedmutations on the identified virulent factors. It takes a shorter period of timeto obtain attenuated MLV vaccine candidates.Applications: Swine Vaccine CandidatesPatent Status: PCT application filed in April 2017.Kansas State University Research Foundation seeks to have discussions with companies that are interested in licensing and/or research collaborations.Interested parties should contact:Kansas State University Institute for Commercialization (KSU-IC)2005 Research Park Circle, Manhattan, KS 66502Tel: 785-532-3900; Fax: 785-532-3909E-Mail: ic@k-state.edu
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