亚洲知识产权资讯网为知识产权业界提供一个一站式网上交易平台，协助业界发掘知识产权贸易商机，并与环球知识产权业界建立联系。无论你是知识产权拥有者正在出售您的知识产权，或是制造商需要购买技术以提高操作效能，又或是知识产权配套服务供应商，你将会从本网站发掘到有用的知识产权贸易资讯。

返回搜索结果

Novel Ligands for HIV-1 Protease Inhibitors

总结: Purdue University researchers have designed and synthesized a novel class of HIV-1 protease inhibitors, which show potency 10x greater than that of Darunavir, an FDA-approved inhibitor developed by the same researchers. A number of these inhibitors are very potent against multidrug-resistant HIV-1 variants and could lead to additional drugs used in HIV/AIDS treatment.

技术优势: HIV therapeutic with 10-fold potency increase over current standardEffective for the treatment of multidrug-resistant strains of HIV

*Background: The AIDS epidemic is one of the most challenging problems in medicine in the 21st century. A retrovirus designated human immunodeficiency virus (HIV) is the etiological agent of the acquired immune deficiency syndrome (AIDS), a complex disease that includes progressive destruction of the immune system and degeneration of the central and peripheral nervous system. Among many strategies to combat this disease, highly active antiretroviral therapy (HAART) with HIV protease inhibitors (PIs) in combination with reverse transcriptase inhibitors (RTIs) continues to be the first-line treatment for control of HIV infection. This treatment regimen has definitely improved quality of life, enhanced HIV management, and halted the progression of the disease. Today, more people than ever before are living with HIV/AIDS thanks to this first-line treatment. However, despite the impressive success, there remain many challenges to treating this devastating disease, including decreasing both the toxicity and complexity of the treatment regimens. In addition, there is a growing population of patients that are developing multidrug-resistant strains of HIV, and there is ample evidence that these strains can be further transmitted.

*Web Links: Purdue Office of Technology CommercializationPurdueInnovation and EntrepreneurshipArun GhoshGhosh GroupPurdue Chemistry

欲了解更多信息，请点击这里