G-Protein Inhibitors for Treatment of Atrial Fibrillation
- 技术优势
- SelectivePotential forpersonalized AF therapy
- 详细技术说明
- Treatment for atrial fibrillation (AF) by modulation of nerves in the heart muscle using inhibitors of G protein signaling #cardiology
- *Abstract
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In collaboration with industry partners, a scientist from Northwestern University has developed a novel strategy for treating atrial fibrillation (AF). Their innovative approach relies on modulating the autonomic nervous system in the heart using G protein inhibiting peptides, which enter the heart muscle and interrupt the aberrant signaling. Given that AF is the most common heart rhythm disorder, developing novel treatment modalities is imperative. In laboratory studies performed to date, G protein inhibiting peptides could be delivered by injection to selectively inhibit AF formation. This invention holds promise for development into a therapetic for AF, but may also contribute to G protein signaling and autonomic nervous system research fields.
- *Inventors
- Rishi Arora*Alan KadishAnnette Gilchrist
- *Publications
- Aistrup GL, Villuendas R,Ng J, Gilchrist A, Lynch TW, Gordon D, Cokic I, Zhou R, Dean DA, WasserstromJA, Goldberger JJ, Kadish AH, Arora R (2009) Targeted G-Protein Inhibition as aNovel Approach to Decrease Vagal Atrial Fibrillation by Selective ParasympatheticAttenuation, Cardivoascular Research,83: 481-92.
- 国家/地区
- 美国
