High-Throughput Drug Screening Assays Using SMPL Nanodiscs
- 技术优势
- • Cell-free plasma protein proteasome library system • Novel ligand receptors discovery • Compound libraries high throughput screening
- 详细技术说明
- Cell-free proteome library and high-throughput drug screening assays for ligand-receptor interaction studies#researchtool #reagent #screening #assay
- *Abstract
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Northwestern researchers have developed a cortical synaptosome plasma membrane proteome library and a high throughput screening method for determination of novel ligand receptors and receptors antagonist.
Ligand-receptor interaction studies are not easy to study on cell-free systems; and membrane proteins difficult to isolate and study without losing their native properties. Northwestern researchers have successfully applied Nanodisc technology, isolating the plasma membrane proteome from a rat cortical synaptic cell line, conferring a unique material to study hundreds or thousands of isolated membrane proteins on a cell-free system.
Northwestern researchers have successfully applied this technology to study ADDLs interaction with its receptors and the detection of antagonists able to block these interactions.
- 国家/地区
- 美国
