Biomarkers for Diagnosis of Depression and PTSD
- 技术优势
- • First biological diagnostic for both depression and PTSD• Improved management of at-risk patients • Reduced misclassification of behavior
- 详细技术说明
- Novel blood test foraccurately diagnosing depression and post-traumatic stress disorder#diagnostics #marker #healthcare #diagnostictool #psychiatry #depression
- *Abstract
-
Northwestern researchers have discovered a set ofgenes whose expression levels differ in the blood of animals that show either highor low levels of depressive behavior. Prof. Eva Redei and colleagues identifieda set of genes differentially expressed in the blood of adolescents and adultswith major depressive disorder (MDD) and biomarkers for post-traumatic stressdisorder (PTSD), which can sometimes co-occur with depression. Currently, thereare no biological diagnostic tools for depression and PTSD. In addition, there are no predictive tools to helpclinicians determine how a particular patient will respond to therapy. However,the discoveries of these sets of biomarkers could enable clinicians to rapidlyand unequivocally diagnose patients and determine the optimal course oftreatment. Introduction of these tests into the clinic may improve patientoutcomes by reducing the risk of inaccurate diagnosis as well as facilitatingmanagement of at-risk populations.
- *Inventors
- Eva Redei* Brian Andrus
- *Publications
- 1. Pajer K, Andrus BM, Gardner W, Lourie A, Strange B, Campo J, Bridge J, Blizinsky K, Dennis K, Vedell P, Churchill GA and Redei EE (2012) Discovery of blood transcriptomic markers for depression in animal models and pilot validation in subjects with early-onset major depression. Translational Psychiatry. 2: e101. 2. RedeiEE, Andrus BM, Kwasny MJ, Seok J, Cai X, Ho J, Mohr DC (2014) BloodTranscriptomic Biomarkers in Adult Primary Care Patients With Major DepressiveDisorder Undergoing Cognitive Behavioral Therapy, Transl Psychiatry. 4: e442.
- 国家/地区
- 美国
