Enhanced CD8+ CTL formation for Adoptive Cell Therapies
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- 详细技术说明
- Compositions and methods that direct ex vivo cultured T cells to a Cytotoxic T lymphocyte (CTL) fate in a T helper cell independent manner.
- *Abstract
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A method for enhanced ex vivo stimulation of cytotoxic CD8+ T lymphocytes (CTL), independent of CD4+ T helper cells, for improved Adoptive Cell Therapy (ACT). Inhibiting tyrosine phosphatase PTPN2 achieves greatly enhanced T-cell stimulation, compatible with the challenging ex vivo activation of tumor infiltrating lymphocytes.
• Method to stimulate ex vivo CTL populations for ACT in a T-helper cell independent manner
• Compatible with the ex vivo reinvigoration of 'tolerised' T-cells or tumour antigen specific CAR-T cells
• 'Proof of Mechanism' in vivo efficacy
• Potential use in single agent and combination therapy applications
- 国家/地区
- 美国
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