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Nurr1 as a Genetic Target for Treating Levodopa-induced Dyskinesias (LIDs) in Parkinson's Disease

详细技术说明

Executive Summary Patients afflicted with Parkinson’s disease often develop severely debilitating movement disorders as side effects from currently available treatment options. Researchers at MSU propose to use a new gene therapy approach that will both reduce these side effects and prolong the effectiveness of treatment by targeted gene silencing. Description of Technology L-Dopa induced dyskinesia (LID) is a side effect of prolonged chronic use of L-Dopa medication. A hyper-expression of Nurr1 protein in affected brain areas might underlie these side effects. Local injection of vectors encoding target genes in affected striatum can directly prevent the hyper-expression allowing for potentially improved fine-tuned response for motor control. Key BenefitsImproved quality of life for Parkinson’s patientsImproved and prolonged benefit for movement disorders ApplicationsTreatment of LID in patients with Parkinson’s diseasePotentially useful in the treatment of other movement disorders Click Here to View a Poster on this Technology Presented by the Inventors Click Here to View a Second Poster on this Technology Presented by the Inventors Patent Status:   Patent pending Licensing Rights Available Full licensing rights available Inventors: Fredric Manfredsson, Kathy Steece-Collier, Jack Lipton, Timothy Collier, Nicholas Kanaan, Caryl Sortwell Tech ID: TEC2014-0099 Alternative contact due to temporary leave: Nina (Isi) Davis, Technology Marketing Manager, email: davisnin@msu.edu, phone (direct): (517)884-1829.

*Abstract

None

*Principal Investigation

Name: Fredric Manfredsson, Assistant Professor

Department: Transitional Science & Molecular Medicine

Name: Kathy Steece-Collier, Professor

Department: Translational Science and Molecular Medicine

Name: Jack Lipton, Chairperson

Department: Translation Science & Molecular Medicine

Name: Timothy Collier, EA Brophy Chair

Department: Translational Science and Molecular Medicine

Name: Nicholas Kanaan, Assistant Professor

Department: Translational Science and Molecular Medicine

Name: Caryl Sortwell, Professor

Department: Translation Science & Molecular Med

国家/地区

美国