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Novel Therapeutics for the Treatment of Nicotine and Alcohol Addiction

详细技术说明: Our scientists have identified a protein-protein coupling between the α7 nicotinic acetylcholine receptor (α7nAChR) and the NR2A subunit of the N‐methyl‐D‐aspartate (NMDA) glutamate receptor as a novel target for treatment of nicotine and alcohol addiction. By characterizing the receptor‐receptor interaction we have developed a peptide that interferes with this coupling leading to the development of a breakthrough therapy capable of delivering enhanced affinity, efficacy, and a superior side effect profile.

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