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Novel Therapeutics for the Treatment of Multiple Sclerosis (MS)

详细技术说明: Our scientists have identified a protein‐protein coupling between the glutamate R2 (GluR2) ‐ α‐amino‐3‐hydroxy‐5‐methylisoxazole‐4‐propionic acid (AMPA) receptor and the extracellular protein glyceraldehyde‐3‐phosphate dehydrogenase (GAPDH) as a novel target for the treatment of the neurodegenerative effects of multiple sclerosis (MS). By characterizing the protein‐protein (GluR2‐GAPDH complex) interaction we have developed a peptide that interferes with this coupling thereby leading to the development of a breakthrough therapy capable of delivering enhanced affinity, efficacy, and a superior side effect profile.

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