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Nanopreparation for Co-Delivery of Drugs and siRNA

技术优势

The nano-preparation:ΓÇóComprises a novel tri-block co-polymeric systemΓÇóExhibits an excellent serum stability and protection of condensed siRNA against enzymatic degradationΓÇóHas an enhanced cell penetration resulting in efficient transfection as compared to conventional approachesΓÇóIs lesser cyto-toxic and immunogenic in the systemic circulation as compared to conventional formulationsΓÇóAllows for a significantly higher cellular uptake of siRNA as compared to conventional compositionsΓÇóExhibits a higher micellization ability with a higher drug loading efficiencyΓÇóWould be commercially useful for treatment of various indications such as multi-drug resistant cancer

详细技术说明

None

*Abstract

Currently, many siRNA delivery technologies are available. However, it is extremely challenging to use these technologies for various therapeutic applications. Some of the most common challenges are associated with effective and non-toxic delivery of siRNA to the site of action, as well as effective transfection into the target cells. Degradation by endogenous enzymes, large size and high negative charge are some of the major issues associated with siRNAs. This invention discloses a novel nano-preparation for co-delivery of drugs and siRNA moieties.

*Principal Investigation

Name: Swati Biswas

Department:

Name: Vladmir Torchilin

Department:

国家/地区

美国