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Releasable Magnetic Cell Capture System

技术优势

The system:ΓÇóIs multifunctional, comprising target specific magnetic nanoparticlesΓÇóEnables an effective control of particle size, ranging from 600-800 nmΓÇóIs highly simple, specific, versatile and cost effective as compared to conventional techniquesΓÇóAllows for a rapid detection as compared to the existing techniquesΓÇóIs capable of capturing few hundred cells/ml of blood sample, with possibility of further lowering the detection limitΓÇóAllows for an efficient release of captured particles using a competitive binding based approachΓÇóCompletely avoids alteration of cellular behavior of the captured cells as compared to conventional systemsΓÇóEffectively capture and purify cells in vitro from blood, plasma, saliva and other body fluidsΓÇóWould be commercially useful for the following applications:o Disease diagnostics and monitoringo Separation and purification of cancer cells such as thyroid, lung, breast, pancreas, and ovaryo Separation of intracellular parasite infection, infectious pathogens and microorganisms from body fluids, tissue samples, food and watero Capturing and separation of rare molecular markers for human and/or animal diseaseso Understanding physiological, biochemical and genetic profile of less understood systems such as circulating tumor cells

详细技术说明

None

*Abstract

In prior art, there is no known technique for effective capturing, purification and isolation of cells. Some existing cell capture techniques are available, which are associated with many possible limitations such as undesirable cellular physiological and morphological changes as well as induction of stress to captured cells. Moreover, the current state of art system (microfluidic based system) for capturing circulating tumor cells doesnΓÇÖt support/allow successful release of captured cells for further study and analysis. This approach discloses a novel, releasable magnetic cell capture system for an effective cellular separation and analysis

*Principal Investigation

Name: Mansoor Amiji

Department:

Name: Amit Singh

Department:

国家/地区

美国