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Macrophage-Targeted Multi-Compartmental Delivery Systems

技术优势

The composition:ΓÇóIs a multi-compartmental nanoparticulate delivery system (nanoparticles encapsulated within a microsphere) for safe and efficient delivery of agentsΓÇóHas an ability to overcome various intra and inter tissue barriers and to effectively deliver the agents at desired biological sitesΓÇóHas an ability to effectively compartmentalize various system components/delivery agents to improve the overall structural stability and to avoid any potential incompatibility issuesΓÇóIs capable of simultaneously delivering incompatible agents (such as hydrophilic and lipophilic agents)ΓÇóAllows for temporal control over the release of agentsΓÇóWould be effectively used for various commercial applications such as disease diagnosis, imaging, gene therapy, gene silencing, cancer treatments, and vaccination

详细技术说明

None

*Abstract

Macrophages play an important role in regulating biological processes, mainly related to inflammatory and infectious diseases. These macrophages get converted from a rested state into an active state to tackle such disorders, wherein the activation is mediated by key activation sources such as cytokines (such as IFN-?) and certain microbial products (such as lipopolysaccharides). This novel approach enables the development and use of compositions for delivery of imaging or therapeutic agents to macrophages.

*Principal Investigation

Name: Mansoor Amiji

Department:

Name: Husain Attarwala

Department:

Name: Shardool Jain

Department:

Name: Mayur Kalariya

Department:

国家/地区

美国