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Retina Extracellular Matrix Based Biomaterials

技术优势

The biomaterial:ΓÇóIs a natural matrix material providing 3D structural and biochemical cuesΓÇóIs quickly absorbed, without containing potentially harmful synthetic substancesΓÇóIs intended to act as a cell delivery vehicle rather than a scaffold for tissue regenerationΓÇóIs capable of providing precise biomimetic structural and biochemical cues as compared to conventional materialsΓÇóEffectively promotes migration, integration, and differentiation of clinically relevant photoreceptorsΓÇóWould be commercially useful for the following applications:o Retinal cell cultureo Treatment of retina based degenerative diseases such as macular degeneration, retinitis pigmentosa, and other retinopathies

详细技术说明

None

*Abstract

Current treatment strategies for retinal degeneration (such as gene therapy, anti-angiogenic therapy, and growth factor treatment) focus mainly on slow degeneration, wherein the majority of implanted cells die. Some of the other key limitations associated with existing strategies are use of polymeric scaffolds with flat (2D) surfaces, potential cell loss, low integration, obstructed trabecular outflow and intraocular inflammation. Moreover, inter-photoreceptor matrix (IPM) and retinal extracellular matrix (ECM) are known to play key roles in development, photoreceptor function, and cellular signaling; however, these materials have never been investigated as a cell scaffold material. This invention discloses novel, retina extracellular matrix based biomaterials of different developmental ages, chemical modifications and species, having potential to overcome existing limitations/unmet needs.

*Principal Investigation

Name: Rebecca Carrier

Department:

国家/地区

美国