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Prognostic Marker for Aggressive Prostate Cancer

技术应用

Prognostic marker Cancer therapy

详细技术说明

UCF researchers have profiled a genome-wide miRNA array and identified a specific cluster of miRNAs that are involved in the transition of androgen dependent prostate cancer cells to androgen independent prostate cancer cells. The identified miRNAs and its target protein could be further developed for use as biomarkers and/or therapeutic targets for drug resistant and castration resistant prostate cancer.

*Abstract

Prostate cancer is one of the leading causes of cancer deaths among men in the United States. Most of these deaths are due to advanced prostate cancer, defined as cancer that has spread beyond the prostate. The standard treatment for advanced prostate cancer is androgen deprivation therapy (ADT) which reduces the levels of male hormones. However, prolonged ADT can lead to the growth of androgen independent cells and the development of an aggressive form of prostate cancer known as castration-resistant prostate cancer (CRPC). The exact mechanism by which CRPC develops is not known, but altered expression of microRNAs (miRNAs) ΓÇô small noncoding RNAs that regulate gene expression ΓÇô is thought to have a significant role.

*Principal Investigation

Name: Ratna Chakrabarti, Ph.D.

Department:

Name: Richard Ottman

Department:

国家/地区

美国