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Novel Modification of Medical Prostheses

技术优势

- A durable and resilient two-layer coating that is applicable to both metallic and non-metallic surface- Slow release of antimicrobial or other therapeutic agents for an extended period of time- All the coating compositions are safe, bio-friendly, and inexpensive- Fast coating process

详细技术说明

None

*Abstract

In-dwelling medical devices such as catheters and orthopedic devices are becoming essential to patient care; however, their benefit is often offset by infectious complications. Colonization of bacteria/fungi on the surfaces of the implant or other parts of the device can produce serious patient problems, including the need to remove and/or replace the implanted device and to vigorously treat secondary infective conditions.Drs. Darouiche and Mansouri have developed a novel two-layer coating method for both metallic and non-metallic medical devices and implants. The first layer comprises of a therapeutic/antimicrobial agent, an acidic component, and a matrix component, such as hide powder and collagen. After air drying, a second protective layer comprising a cyanoacrylate or its derivatives will be applied on top of the first layer to prevent its rapid dissolution in an aqueous environment. Comparing to existing methods, this technology is superior physically, chemically, and biologically. First, the coating on the devices is more hardwearing and resilient than the previous methods. Moreover, it enables the device to release the drugs, such as antibiotics, in a concentration-controlled fashion over an extended period of time. In addition, all the layer components are biocompatible.

附加资料

Patent Number: US7238363B2
Application Number: US200595975A
Inventor: Mansouri, Mohammad D. | Darouiche, Rabih O.
Priority Date: 2 Apr 2004
Priority Number: US7238363B2
Application Date: 31 Mar 2005
Publication Date: 3 Jul 2007
IPC Current: A61F000200 | A61L000200 | A61L002754 | A61L002916 | A61L003116 | A61L003300
US Class: 424423 | 42700224
Assignee Applicant: Baylor College of Medicine,Houston
Title: Modification of medical prostheses
Usefulness: Modification of medical prostheses
Summary: For coating medical device such as catheter selected from peripherally insertable central venous catheter, dialysis catheter, long term tunneled central venous catheter, peripheral venous catheter, short-term central venous catheter, arterial catheter, pulmonary artery Swan-Ganz catheter, urinary catheter, long term non-tunneled central venous catheter, peritoneal catheter, and ventricular catheter; long term urinary device; tissue bonding urinary device; penile prostheses; vascular graft; extravascular graft; urinary stent; vascular catheter port; wound drain tube; drug delivery system; neurotransmitter; epidural catheter; cerebrospinal fluid draining system; hydrocephalus shunt; pacemaker system; implantable stimulator; implantable infusion pump; ventricular bypass assist device; tissue expander; implantable pulse generator; maxillofacial implant; mandibular implant; contraceptive tubal occlusion device; contraceptive intrauterine device; artificial anal sphincter; artificial urinary sphincter; vascular dilator; extravascular dilator; intravascular stent; extravascular stent; small joint replacement; temporary joint replacement; urinary dilator; heart valve; orthopedic implant; heart assist device; mammary implant; dental device; pacemaker; defibrillator; hip prostheses; knee prostheses; spinal prostheses; shoulder prostheses; joint prostheses; fracture fixation device; external fixation pin; and intramedullary nail, screws, plate, rod and cage (all claimed) to inhibit growth of bacterial and fungal organisms.
Novelty: Coating medical device to inhibit growth of bacterial and fungal organisms involves applying composition containing therapeutic agent, glycerol, acidic and matrix component, and composition containing cyanoacrylate in layers

主要类别

环保/绿色科技

细分类别

空气处理

国家/地区

美国