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BIOMARKERS TO IDENTIFY HIV-SPECIFIC T-CELL SUBSETS

技术优势

Immunology

技术应用

The information regarding the genes that are important in HIV treatment response provides knowledge of additional targets for diagnosis and therapy. The present invention can further be used to generate databases comprising informative genes which will have many applications in medicine, research and industry, and in particular, in treatment of HIV infection.

详细技术说明

The invention provides a method to determine the immune response in an HIV-infected individual by comparing the expression profile of the subjectΓÇÖs HIV-specific T-cells with that of a chronic progressor (individual exhibiting a very high viral load compared to non-HIV infected individuals) or a controller (individual capable of maintaining very low viral load for upto 12 months). The invention identifies the informative genes that are particularly relevant to classify HIV-infected patients in order to predict patterns related to treatment of HIV, monitoring HIV disease progression, classifying immune response to HIV vaccine and survival in HIV infected subjects. The present invention can be effectively used to analyze proteins, peptides, or nucleic acid molecules isolated from sample sources such as blood, plasma, lymph, urine, tissue, mucus, sputum, saliva or other cell samples. The gene expression levels are obtained by hybridizing the sample with a suitable microarray on which probes specific for all or a subset of the informative genes have been immobilized, and determining the extent of hybridization of the nucleic acid in the sample to the probes on the microarray.

*Abstract

The invention provides a method to determine the immune response in an HIV-infected individual by comparing the expression profile of the subjectΓÇÖs HIV-specific T-cells with that of a chronic progressor.

附加资料

Inventor: HAINING, W., Nicholas | EBERT, Benjamin | WALKER, Bruce
Priority Number: WO2011049603A1
IPC Current: G01N003350
Assignee Applicant: Dana-Farber Cancer Institute Inc. | The General Hospital Corporation | The Brigham & Women's Hospital Inc.
Title: BIOMARKERS TO IDENTIFY HIV-SPECIFIC T-CELL SUBSETS | BIOMARQUEURS PERMETTANT D'IDENTIFIER DES SOUS-ENSEMBLES DE CELLULES T SPÉCIFIQUES DU VIH
Usefulness: BIOMARKERS TO IDENTIFY HIV-SPECIFIC T-CELL SUBSETS | BIOMARQUEURS PERMETTANT D'IDENTIFIER DES SOUS-ENSEMBLES DE CELLULES T SPÉCIFIQUES DU VIH
Summary: The methods and expression profile are useful for classifying immune response in individual infected with HIV; classifying immune response in individual who has been vaccinated with HIV vaccine; increasing HIV specific T-cell function in HIV-infected subject; increasing survival of HIV-specific T-cells in HIV-infected subject; treating HIV infection in subject; monitoring efficacy of anti HIV therapy in HIV infected subject; selecting anti-HIV therapy for HIV infected subject; monitoring HIV disease progression in HIV infected subject undergoing HIV treatment; determining prognosis of HIV infected subject; identifying HIV infected subject as chronic progressor; identifying HIV infected subject as controller; and for determining expression profile of HIV infected subject (all claimed).

主要类别

诊断/治疗

细分类别

人类免疫缺陷病毒

国家/地区

美国