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Immunoassay for detection of SCID (severe combined immunodeficiency) in newborns

技术优势

Immunoassays are used routinely in NBS as a first-tier screening protocol, therefore the multiplex immunoassay presents as a viable alternative or complement to the TREC assay in detecting SCID.Low cost rapid test (Immunoassay vs. DNA testing)For markets where DNA/TREC Assay testing equipment is not widely available i.e. Brazil, Asia.Additiional markets exist in populations where SCID is prevalent but DNA testing is culturally unacceptable i.e Native Americans

技术应用

Immunoassay for Newborn screening panel Severe Combined Immunodeficiency (SCID).Alternative test for identifying other T-cell immunodeficiencies

详细技术说明

Using the Guthrie specimen, our immunoassay utilizes novel antibodies against CD3 epsilon peptides as a marker for T-cell deficiency. This assay is very promising as a viable alternative or complement to the TREC assay for detecting SCID in a Guthrie specimen.

*Abstract

Severe Combined Immunodeficiency (SCID) presents as one of the greatest opportunities for newborn screening (NBS), and also one of its most difficult challenges. The defining characteristic is always a severe defect in T-cell production and function, with defects in B-lymphocytes as a primary or secondary problem. This is the first and only condition on the newborn screening panel of 30 genetic diseases that is curable if identified and treated in early infancy.

*IP Issue Date

Oct 29, 2013

*IP Type

Utility

国家

United States

附加资料

Inventor: PASS, Kenneth, A. | LINDAU-SHEPARD, Barbara | JANIK, David, K.
Priority Number: WO2011109588A1
IPC Current: A61K003804
Assignee Applicant: Health Research Inc.
Title: NOVEL CD3 EPSILON IMMUNOGENS AND ANTIBODIES | NOUVEAUX IMMUNOGÈNES ET ANTICORPS CD3 EPSILON
Usefulness: NOVEL CD3 EPSILON IMMUNOGENS AND ANTIBODIES | NOUVEAUX IMMUNOGÈNES ET ANTICORPS CD3 EPSILON
Summary: The isolated CD3 ε peptide is useful for diagnosing immunodeficiency, preferably severe combined immunodeficiency and T cell immunodeficiency in patient (all claimed).
Novelty: New isolated cluster of differentiation 3 epsilon peptide, useful for diagnosing immunodeficiency e.g. severe combined immunodeficiency in patient, comprises amino acid sequence

主要类别

诊断/治疗

细分类别

其他疾病

申请号码

8,569,450

国家/地区

美国