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Directed Spontaneous Assembly of Membrane Protein with Amphiphilic Block Copolymers

技术优势

Main Advantages of this InventionΓÇó DoesnΓÇÖt use unstable liposomesΓÇó Spontaneously orderedΓÇó Membrane could be in entangled or glassy states

技术应用

Potential Areas of Application ΓÇó Biosensor designΓÇó High-throughput drug-screeningΓÇó Catalysis

详细技术说明

None

*Abstract

This invention describes a method for using membrane proteins (MPs) in synthetic systems for biosensor design, high-throughput drug-screening, catalysis or energy harvesting. Current efforts in the art face a challenge that practical applications involving liposomes have been continually hindered by their lack of stability. This invention used polymersome membranes as structural materials to support MP functions in lieu of biologically-derived lipid bilayers. A series of amphiphilic block copolymers with systematically varied membrane-forming blocks were designed. Investigation of the design found that charge-interaction directed assembly paradigm is applicable to the polymersome system to induce the formation of 3-D hierarchically ordered proteopolymersome membranes spontaneously, even when the membrane block is in entangled or glassy states

*Principal Investigation

Name: Hongjun Liang

Department:

国家/地区

美国