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A new class of HDAC inhibitors expands the renal progenitor cells population and improves the rate of recovery from acute kidney injury

详细技术说明

None

*Abstract

BackgroundAcute kidney injury (AKI) has a high mortality and morbidity that has not decreased over the last twenty years. Since innate renal tubular regeneration occurs after tissue injury, there has been considerable interest in the development of treatments that enhance the regenerative capacity of the kidney when administered after induction of injury. This would be a significant advance in the field, since most therapies for AKI, which have shown potential when administered prior to the onset of renal injury in experimental models, have failed to show therapeutic benefit in humans. TechnologyInvestigators have identified a novel class of histone deacetylase inhibitors which cause expansion of renal progenitor cells during embryonic development. There is evidence that the analogue accelerates renal recovery in a mouse model of AKI when given after induction of injury. Investigators have generated multiple analogues to find compounds that have high target efficacy and low toxicity.Provisional Patent Application filed

*Principal Investigation

Name: Billy Day, Professor

Department: Pharm-Pharmaceutical Science

Name: Neil Hukriede, Assistant Professor

Department: Med-Developmental Biology

国家/地区

美国