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Sulfonylurea Glyburide as a Novel Radioprotecting Agent

详细技术说明

None

*Abstract

The inventors have discovered a novel application of a clinically used drug, namely the second-generation sulfonylurea glyburide as a protectant against lethal ionizing radiation. Glyburide and pharmacologically related chemicals may be used to protect cells and organisms, including humans, against the harmful effects caused by exposure to ionizing radiation from therapeutic, accidental or terroristic use. Applications* Valuable for firefighter, police, workers or soldiers that must enter areas, which are heavily contaminated with radiation. * Protection against untoward radiation toxicity that occurs after therapeutic doses of radiation. * Useful for astronauts, who will be exposed to radiation due to space travel. Advantages* Inexpensive compound and concept to develop, as glyburide is already available from multiple sources. Provisional Patent Application filedBackgroundThe identification and development of effective radioprotectors and mitigators is of considerable importance because of the common application of ionizing radiation (IR) in medical practice, possible accidental exposure to radiation and potential exploitation of radiation by terrorists. Unfortunately,currently there are no approved drugs to prevent acute radiation syndrome, despite extensive exploration.

*Principal Investigation

Name: Michael Epperly, Associate Professor

Department: Med-Radiation Oncology

Name: Joel Greenberger, Professor & Chairman

Department: Med-Radiation Oncology

Name: Janfei Jang

Department: Radiation Oncology

Name: Valerian Kagan, Professor and Vice Chairman

Department: GSPH-Environmental/Occupational Health

Name: John Lazo, Professor Emeritus

Department: Departments of Pharmacology & Chemistry

Name: Peter McDonald

Department: Med-Pharmacology and Chemical Biology

国家/地区

美国