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Endothelial Specific Targeting by Oligo-Peptides (Endo Stop)

详细技术说明

None

*Abstract

Peptide motifs which define specificity of tumor-derived endothelial cells. These peptides possess a charge motif of positive-positive-hydrophobic which is important in determining the specificity of binding to tumor-derived endothelium. The specific molecular peptide motifs will facilitate diverse therapeutic and diagnostic applications including: anti-angiogenic therapies to be used in alone or in conjunction with standard therapies; imaging tools for both detection of very small metastasis that are undetectable by current techniques; for monitoring tumor response; for targeting and directing chemotherapy drugs to the tumor; for treatment of chronic inflammatory diseases such as rheumatoid arthritis and psoriasis, for treating some forms of blindness; as well as other diagnostic and therapeutic applications. Embodiments of the present invention include purified peptide fragments with selective binding to tumor-derived endothelial cell, wherein the peptide fragment possesses a charge motif of positive-positive-neutral hydrophobic ( O). In a preferred embodiment, these purified peptide fragments have an amino acid length of between 2 and 50 residues. A further embodiment of the invention includes the purified peptide fragments described above wherein the peptide fragment is operatively attached to a therapeutic agent capable of exerting a cytotoxic effect on tumor vasculature. Furthermore, this peptide fragment operatively attached to a therapeutic agent may exert a cytotoxic effect on tumor vasculature sufficient to lead to tumor necrosis. Additionally, these peptide fragments may be formulated as a pharmaceutical composition.

*Principal Investigation

Name: Charles Brown, Biologic Therapy Fellow

Department: Med-Surgery

Name: Candace Johnson, Senior VP Translational Research

Department: Med-Pharmacology and Chemical Biology

Name: Ruth Modzelewski, Instructor

Department: Med-Medicine

Name: Donald Trump, Professor

Department: Hematology & Oncology

Name: Michael Wong, Assistant Professor

Department: Med-Medicine

国家/地区

美国