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Gene-Expression Signatures that Identify Cirrhosis Patients "At Risk" for Liver Cancer and Predict the Probability of HCC Recurrence Following Early-Stage Diagnosis and Resection

*Abstract: Knowing an individualΓÇÖs susceptibility to cancer recurrence in advance could lead to significant health gains as well as lower health costs. There is an urgent need to (1) identify "at risk" patients, and (2) sort out those patients with the greatest risk of experiencing cancer recurrence after "standard of care" chemotherapy so that appropriate treatment decisions can be made. Gene-expression profiling of cancer is an effective method to do such "sorting." Scientists in the Golub lab discovered and validated two different gene expression signatures that predict either a poor survival outcome (73 gene signature) or good survival outcome (113 gene signature) in early stage hepatocellular cancer ("HCC") (liver cancer) patients.

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