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Bismuth Complexes as Antimicrobial Agents

总结: Thermally stable, safe, non-toxic additives for the development of a large range of antimicrobial products - including synthetic and natural (cellulose) polymer based materials - such as medical devices, packaging and surface coatings. Primary results demonstrate efficacy comparable to commercial products, including against resistant bacterial strains.

技术优势: - Antibacterial efficacy comparable to silver
- Potential low toxicity in humans
- Suitable for incorporation into a broad range of products due to thermal stability features

详细技术说明: Monash researchers have developed metal- organic bismuth based complexes that demonstrate antibacterial activity against Gram negative and Gram positive bacteria, including multidrug-resistant strains (MRSA and VRE).
Bismuth compounds (Pepto-Bismol) are already widely used for the treatment of gastrointestinal disorders and are safe to use.
Independent tests on our bismuth compounds show activity comparable with commercial (silver) antibacterials. Proof-of- concept studies encompass inclusion in agar, polymer and cellulose based materials.

其他: Monash seeks a partner to further develop this technology. The research term, led by Prof Phil Andrews and Dr Melissa Werrett, has extensive experience in organometallic and medicinal chemistry with a particular focus on synthesis, structure development and bismuth complese for targeted applications.

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