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Embryonic and adult stem cells encapsulation for cell based therapy and cancer (Technion)

总结

Stem cells are potentially the ultimate source of transplantable cells for many different tissues. These cells seem to have an unlimited capacity to propagate in culture conditions, while remaining undifferentiated. Furthermore, upon differentiation these cells can transform into many cell types. Stem cells have also been tested successfully for genetic manipulation and gene targeting and cell-based therapy. However, a major obstacle for the clinical use of stem cells is their possible immunogenicity. To date, there is insufficient information regarding the relationship between stem cells and the immune system.
Our technology focuses on engineering stem cells to produce therapeutics, particularly cancer inhibitors. In addition the cell can be manipulated to become, for example, pseudo pancreatic cells secreting insulin. Technion researchers' innovative approach is to entrap the cells in capsules made of biocompatible polymers. This approach was specifically designed to take advantage of the immortality of these cells, while avoiding any possible immune response or the formation of teratomas. These capsules will protect the cells from the immune system and act as a minibioreactor, which will allow them to secrete the engineered factor or natural therapeutic near sites of interest. System advantages:
Low immunogenicity.
Possibly autologous.
Self-renewal, cells Maintained in an undifferentiated state.
May be transfected with exogenous genes.
Prevent embryonic stem cells that become teratomas to filtrate to their surroundings.

技术应用

Investigating the therapeutic efficacy of encapsulating stem cells. Especially those engineered to secrete cancer inhibitors for cancer therapy or other therapeutics.
Investigating the entrapment of stem cells in microcapsules, composed of biocompatible polymers. The microcapsules will allow separation of the cells from their niche, the polymeric membrane will act as a barrier between the stem cells and their surroundings. With the capsule system the cells are unable to "escape" and can differentiate only to the cell type previously chosen.

ID号码

STM-0956

国家/地区

以色列