3D Matrices for Growing and Differentiating Progenitor and Stem Cells (Yissum)
Highlights:
- All epithelial tissues in nature interact with an extracellular matrix. In spite of this, traditional cell culture is carried out on monolayers in plastic and does not take into account the interrelationships of other cells in tissue
- These new methods use novel 3D organ-specific matrices as a more natural environment to culture all types of cells and to manipulate stem cells into specific organs
Our Innovation:
- Broad platform technology using three-dimensional, organ-specific matrices for growing different types of cells, including stem cells, ex vivo
- Organ-specific matrices induce stem cells to differentiate into required organ
- Isolation of specific stem cells from a mixture of early-differentiating stem cells through their their binding affinities to organ-specific matrix regions
Key Features:
-◾Matrix is specific for any type of organ; encourages stem cells to differentiate into pathways normally followed by cells of that specific organ
-◾Method for preparing engineered organs to be used in vitro or for transplantation in vivo
- Can use adult or embryonic stem cells to generate organized engineered tissue
- Potential products include: 1de.
Tissue engineering and stem cells revenues in excess of $10 billion by 2013
Patent published in Europe, allowed in United States, filed in Israel
PCT publication number: WO 03/060062
In-vitro proof of concept in various engineered tissues
6-2006-38
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