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COMPOUNDS AND METHODS FOR THE TREATMENT OF PROLIFERATIVE DISEASES

总结

Cell-based and cell-free assays are disclosed that detect compounds that promote aggregation of proteins, glycoproteins, and protein-nucleic acid complexes. Also disclosed are pharmaceutical formulations useful for treating or preventing viral infections, bacterial infections, cancer, and diseases involving hyper-proliferative cells.

附加资料

Patent Number: US20120142701A1
Application Number: US13149056A
Inventor: Kao, Yi Tsun Richard | Yuen, Kwok-Yung
Priority Date: 28 May 2010
Priority Number: US20120142701A1
Application Date: 31 May 2011
Publication Date: 7 Jun 2012
IPC Current: A61K0031496 | A61P003104 | A61P003112 | A61P003116 | A61P003500 | C07D041706 | C12Q000168 | G01N003353 | G01N0033566
US Class: 51425404 | 43500619 | 4350071 | 436501 | 544367
Assignee Applicant: The University of Hong Kong
Title: COMPOUNDS AND METHODS FOR THE TREATMENT OF PROLIFERATIVE DISEASES
Usefulness: COMPOUNDS AND METHODS FOR THE TREATMENT OF PROLIFERATIVE DISEASES
Summary: The method is useful for identifying a compound (that promote cytoplasmic nucleoprotein aggregation of proteins, glycoproteins, or protein-nucleic acid complexes), useful in formulations to treat or prevent viral infection, bacterial infection, cancer, a hyper-proliferative disease, and influenza A infection (including H1N1, H3N2, and H5N1) (all claimed). Test details are described but no results given.
Novelty: Identifying compounds that promote aggregation, used to treat e.g. viral infection, comprises e.g. treating cells with a test compound, adding fixing solution to stop protein translation, and treating cells with a fluorescent antibody

主要类别

诊断/治疗

细分类别

癌症/肿瘤

申请号码

13/149,056

国家/地区

美国