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Removal of Endotoxin using Amphiphilic Core-shell nanosorbents

总结: Method for removal of endotoxin from protein preparations using core-shell nanoparticles, which have the ability to selectively adsorb endotoxin molecules in a protein mixture. The method comprises the steps of (a) preparing a plurality of core-shell nanoparticles; (b) adding the core-shell nanoparticles into a protein preparation containing endotoxin; (c) incubating the core-shell nanoparticles with the protein preparation for a period of time; and (d) separating nanoparticles from the protein preparation.

附加资料: Patent Number: US8669354B2
Application Number: US13163764A
Inventor: Li, Pei | Ho, Kin Man
Priority Date: 26 Jan 2009
Priority Number: US8669354B2
Application Date: 20 Jun 2011
Publication Date: 11 Mar 2014
IPC Current: C07K000114 | C07K000136 | C40B004004
US Class: 530415 | 4350071 | 4350911 | 4350912 | 530350
Assignee Applicant: The Hong Kong Polytechnic University
Title: Removal of endotoxin using amphiphilic core-shell nanosorbents
Usefulness: Removal of endotoxin using amphiphilic core-shell nanosorbents
Summary: Method for removing endotoxin by utilizing an amphipathic core-shell type nanometer absorbent.
Novelty: Method for removing endotoxin, involves adding core-shell type nano-particles to protein containing endotoxin, incubating core-shell type nano-particles and protein, and separating nano particles from protein

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