Biphenyldiphosphine Compounds
The present invention provides compounds of the formula
wherein
R is optionally substituted lower alkyl, cycloalkyl or aryl;
R′ is alkyl or aryl;
n is zero or an integer of 1 or 2;
or an enantiomer thereof; or an enantiomeric mixture thereof.
The compounds of formula (I) are bridged C2-symmetric biphenyldiphosphine analogs and, thus, may be employed as ligands to generate chiral transition metal catalysts which may be applied in a variety of asymmetric reactions. The compounds of the present invention are easily accessible in high diastereomeric and optical purity according to the methods disclosed herein.
Patent Number: US7094725B2
Application Number: US2004888820A
Inventor: Chan, Albert Sun Chi | Qiu, Liqin
Priority Date: 11 Jul 2003
Priority Number: US7094725B2
Application Date: 9 Jul 2004
Publication Date: 22 Aug 2006
IPC Current: B01J003100 | B01J003122 | B01J003124 | C07F0009655 | C07F001500
US Class: 502150 | 502102 | 502104 | 502152 | 502155 | 502162 | 549270 | 556013 | 556019
Assignee Applicant: The Hong Kong Polytechnic University
Title: Biphenyldiphosphine compounds
Usefulness: Biphenyldiphosphine compounds
Summary: (I) are useful in asymmetric synthesis and manufacture of chiral molecules by the chemical and pharmaceutical industry.
Novelty: New biphenyldiphosphine compounds useful in asymmetric synthesis and manufacture of chiral molecules in the chemical and pharmaceutical industry
化工/材料
化工/材料应用
CHAN Sun-chi Albert
QIU Liqin
美国
