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Novel Polyprenylated Benzoylphloroglucinols with Anticancer Activity

总结: This invention is to provide two new polyprenylated benzoylphloroglucinol derivatives, garciesculentones A and C (compounds 1 and 2), which exhibited cytotoxicity and antimigration effect against the tested human cancer cell lines and have potential to be developed as anticancer drugs.

技术优势: Those novel compounds may have potential to be developed as anticancer drugs.

技术应用: Those novel compounds may have potential to be developed as anticancer drugs.

详细技术说明: The petroleum ether extract and the EtOAc-soluble fraction of the 80% (v/v) EtOH extract of Garcinia esculenta were found to show cytotoxicity against a panel of human cancer cell lines (SMMC-7721, HepG2, MCF-7, and MDA-MB-231). With bioassay-guided fractionation, two novel polyprenylated benzoylphloroglucinol derivatives, garciesculentones A and C (compounds 1 and 2) were isolated from these two bioactive fractions. The structures of new compounds were elucidated by extensive 1D and 2D NMR spectroscopic analyses and mass spectrometry. Compounds 1 and 2 exhibited cytotoxicity against the tested human cancer cell lines. Moreover, these compounds had antimigration effect on ECA109 cells in the absence of cytotoxicity.

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