Autophagy Inducing Compound and the Uses thereof
This relates to a composition including an autophagy inducing compound used to degrade abnormal protein deposit in the nervous system by inducing autophagy and related methods of treatment, such as treating neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease associated with abnormal protein aggregation and/or deposition and cancer.
non-toxicity, effective
Treat Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease, spinocerebellar ataxia, oculopharyngeal muscular dystrophy, prion diseases, fatal familial insomnia, alpha-1 antitrypsin deficiency, dentatorubral pallidoluysian atrophy, frontal temporal dementia, progressive supranuclear palsy, x-linked spinobulbar muscular atrophy, and neuronal intranuclear hyaline inclusion disease and cancer.
The present invention discloses novel compositions including IsoRhy and tetracyclic oxindole alkaloids that induce autophagy in neurons to degrade protein aggregates independent of mTOR both in vivo and in vitro and the application thereof in treating diseases that can benefit from autophagy inducement and free from mTOR associated complications.
诊断/治疗
癌症/肿瘤
2012.03.15
Published
A61/LM/Auto/US01
香港
