亚洲知识产权资讯网为知识产权业界提供一个一站式网上交易平台，协助业界发掘知识产权贸易商机，并与环球知识产权业界建立联系。无论你是知识产权拥有者正在出售您的知识产权，或是制造商需要购买技术以提高操作效能，又或是知识产权配套服务供应商，你将会从本网站发掘到有用的知识产权贸易资讯。
返回搜索结果

穿心蓮內酯環糊精包合物、其制備方法及其應用

标题
穿心蓮內酯環糊精包合物、其制備方法及其應用
总结

Cyclodextrins (CD) are cyclic glucose polymers with usually six (alpha), seven (beta) or eight (gamma) glucose residues. They are shaped like doughnuts with a hydrophobic cores and hydrophilic exteriors. Hydrophobic residues from drug molecules can sit inside the cavity and form a complex which may have various uses. Throughout the last few years, interactions of drugs or bioactive components of herbs with cyclodextrins have been systematically explored by us at CityU. The bioavailability of both indomethacin, an antinflammatory drug and andrographolide, a bioactive components purified from the herb Andrographis, have been successfully improved via our molecular complexation technique.
技术优势

  • contemporary approaches to enhance the dissolution of pharmaceutical preparations have certain problems and do not give the best therapeutic effects

  • by molecular encapsulating it in a cavity molecule, the solubility and bioavailability of a poorly soluble drug could be improved in addition to being protected from degradation

  • different methods have been explored for preparing the encapsulated complexes between guest molecules and cavity molecules, but inclusion complexes prepared by means of spray drying at certain conditions give the best results


技术应用

  • contemporary approaches to enhance the dissolution of pharmaceutical preparations have certain problems and do not give the best therapeutic effects

  • by molecular encapsulating it in a cavity molecule, the solubility and bioavailability of a poorly soluble drug could be
    • molecular encapsulation conditions have been established to produce the micro/nano-size medicinal particulates suitable for use in the manufacture of parenteral or pulmonary pharmaceuticals

    • the solubility, stability and bioavailability of bioactive components isolated from herbal substances could be significantly enhanced

    • this technique could also be applied to other industrial products that require a homogenous, stable and yet controlled rate of release of substance for a particular function


申请日期
26/07/2010
ID号码
201010239957.3
国家/地区
香港

欲了解更多信息，请点击 这里
移动设备