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Uses Of Transgenic Mouse Containing A Type X Collagen Mutant

总结

This Invention Provides An Isolated Dna Comprising The Sequence Which Codes For A Mutated Collagen X Or A Portion Thereof Wherein The Expression Of The Dna Regulates Bone Growth. This Invention Provides A Polypeptide Encoded By The Isolated Dna Comprising The Sequence Which Codes For A Mutated Collagen X Or A Portion Thereof Wherein The Expression Of The Dna Regulates Bone Growth. This Invention Also Provides A Polypeptide Which Comprise The Portion Of The Mutated Collagen X Capable Of Regulating Bone Growth. This Invention Further Provides A Transgenic Animal Comprising An Isolated Dna Comprising The Sequence Which Codes For A Mutated Collagen X Or A Portion Thereof Wherein The Expression Of The Dna Regulates Bone Growth.

附加资料

Patent Number: US6369295B1
Application Number: US1999415551A
Inventor: Cheah, Kathryn S. E. | Cheung, Kenneth M. C.
Priority Date: 8 Oct 1998
Priority Number: US6369295B1
Application Date: 8 Oct 1999
Publication Date: 9 Apr 2002
IPC Current: A01K0067027 | C07K001478 | C12N001512 | C12N001585 | A61K003800 | A61K004800
US Class: 800018 | 4353201 | 435325 | 5360231 | 800003 | 800009 | 800013 | 800014
Assignee Applicant: The University of Hong Kong
Title: Uses of transgenic mouse containing a type X collagen mutant
Usefulness: Uses of transgenic mouse containing a type X collagen mutant
Summary: (IIIa) or (I) is useful for treating a subject afflicted with dwarfism (effective to reverse dwarfism) and for treating a subject with low bone mass (which causes osteoporosis). (IIIa) and (I) are useful for improving the quality and speed of bone union after fracture (all claimed). (I) is useful for obtaining transgenic animal, preferably mouse, comprising (I).
Novelty: Col10-13del DNA encoding mutated collagen X polypeptide, useful for treating a subject afflicted with dwarfism, osteoporosis and for improving speed of bone union after fracture

主要类别

生物医学

细分类别

DNA /基因工程

申请号码

US1999415551A

国家/地区

香港