Synthetic Peptide Targeting Critical Sites On The Sars-Associated Coronavirus Spike Protein Responsible For Viral Infection And Method Of Use Thereof
The Present Invention Provides Methods For Locating Critical Portions Or Sites On The Spike Protein (S Protein) Of Sars-Associated Coronavirus (Sars-Cov) Responsible For The Viral Infection That Causes Severe Acute Respiratory Syndrome (Sars). The Present Invention Also Provides New Synthetic Peptides Targeting Such Critical Portions Or Sites Of The S Protein Of Sars-Cov For Preventing Or Treating Of Sars-Cov Infection In A Subject. The Present Invention Further Provides Methods Of Testing Antiviral Activity Exerted By Antiviral Agents Using Real-Time Quantitative Pcr.
Patent Number: US7491489B2
Application Number: US2005262044A
Inventor: Zheng, Bojian | Guan, Yi | Huang, Jiandong | He, Ming-Liang
Priority Date: 22 Nov 2004
Priority Number: US7491489B2
Application Date: 28 Oct 2005
Publication Date: 17 Feb 2009
IPC Current: C12Q000100 | C12Q000118 | C12Q000170 | G01N003353
US Class: 435004 | 435005 | 4350071 | 43500721
Assignee Applicant: The University of Hong Kong
Title: Synthetic peptide targeting critical sites on the SARS-associated coronavirus spike protein responsible for viral infection and method of use thereof
Usefulness: Synthetic peptide targeting critical sites on the SARS-associated coronavirus spike protein responsible for viral infection and method of use thereof
Summary: (M1) is useful for locating portions of SARS-CoV S protein responsible for causing viral infection in a cell, where the cell is from a primate or human. (M2) is useful for preventing or inhibiting SARS-CoV infection in a subject, where the subject is a cat, horse, sheep, pig, dog, cat, rodent, chicken or primate, or human being. (All claimed).
生物医学
病原
香港
