Use Of Acacetin And Related Compounds As Potassium Channel Inhibitors
This Invention Provides A Method For Treating Or Preventing Human Atrial Arrhythmia (Fibrillation) Using The Leading Flavone Compound Acacetin, And Its Derivatives And Analogues That Inhibit The Ultra-Rapidly-Activating Delayed Rectifier Potassium Current (Ikur Or Iksus), Transient Outward Potassium (Ito), And Acetylcholine-Activated Potassium Current (Ik.Ach).
Patent Number: US8461198B2
Application Number: US2010876621A
Inventor: Li, Gui-Rong | Lau, Chu-Pak | Qin, Guo-Wei | Wang, Hong-Bing
Priority Date: 2 Mar 2007
Priority Number: US8461198B2
Application Date: 7 Sep 2010
Publication Date: 11 Jun 2013
IPC Current: C07D031126 | A61K0031353
US Class: 514456 | 549402
Assignee Applicant: Versitech Limited | Shanghai Institute of Materia Medica Chinese Academy of Sciences,Shanghai
Title: Use of acacetin and related compounds as potassium channel inhibitors
Usefulness: Use of acacetin and related compounds as potassium channel inhibitors
Summary: The composition is useful for: treating or preventing atrial fibrillation in humans; and treating arrhythmias.
Novelty: Composition used to treat e.g. arrhythmias, comprises isolated or synthesized compound e.g. 4-(5-hydroxy-2-(4-methoxyphenyl)-4-oxo-4H-chromen-7-yl)benzoate or 7-ethoxy-5-hydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one and carrier
化工/材料
化工/材料应用
香港
