Novel Compounds and Uses Thereof for Treating Inflammation and Modulating Immune Responses
The present invention provides compounds, and compositions comprising these compounds, which have immunomodulatory activity and/or anti-inflammatory activity.
Inventor: Lau, Allan Sik Yin | Yang, Cindy Lai Hung
Priority Number: US20130324605A1
IPC Current: A61K0031216
US Class: 514532
Assignee Applicant: Versitech Limited | Purapharm Company Limited
Title: USES OF CIMIRACEMATE A AND RELATED COMPOUNDS FOR TREATING INFLAMMATION AND MODULATING IMMUNE RESPONSES
Usefulness: USES OF CIMIRACEMATE A AND RELATED COMPOUNDS FOR TREATING INFLAMMATION AND MODULATING IMMUNE RESPONSES
Summary: For reducing 5-lipoxygenase (5-LOX) activity; for treating disease or condition selected from inflammation, allergy or allergenic reaction, cardiovascular disease, cerebrovascular disease, neoangiogenesis, respiratory or pulmonary disorder, skin disorder, asthma or asthma-related condition, arthritis, and cancer or tumor, in a subject such as human; for inhibiting neoangiogenesis; and for treating disease selected from asthma (such as bronchial asthma), rhinitis (such as allergic rhinitis), chronic obstructive pulmonary disease, cerebrovascular disease, or myocardial infarction, cerebrovascular and/or cardiovascular disease selected from myocardial infarction, acute myocardial infarction, stroke, atherosclerosis, thrombosis, coronary angioplasty, angina, myocardial ischemia, hypertension, platelet aggregation, aortic aneurysms, vascular inflammation, intimal hyperplasia, or hyperlipidemia-dependent aortic aneurysm, and respiratory or pulmonary condition selected from cystic fibrosis, lung diseases, sleep-disorder breathing, obstructive sleep apnea (OSA), and chronic obstructive pulmonary disease (COPD). The cancer or tumor is selected from urological tumor, renal cell carcinoma, bladder tumor, prostate cancer, and pancreatic cancer (all claimed).
Novelty: Reducing 5-lipoxygenase activity and treating disease e.g. inflammation, allergy reaction, cardiovascular disease, cerebrovascular disease, asthma arthritis and cancer involves administering isolated Cimiracemate A compound to a subject
诊断/治疗
癌症/肿瘤
香港
