Strontium fortified calcium nano- and microparticle compositions and methods of making and using thereof
Compositions containing strontium fortified calcium nanoparticles and/or microparticles, and methods of making and using thereof are described herein. The strontium fortified calcium compounds contain calcium ions, calcium atoms, strontium ions, strontium atoms, and combinations thereof and one or more anions. Exemplary anions include, but are not limited to, citrate, phosphate, carbonate, and combinations thereof. The particles can be formulated for enteral or parenteral administration by incorporating the particles into a pharmaceutically carrier. The compositions can further contain one or more active agents useful for bone diseases or disorders, such as vitamin D, growth factors, and combinations thereof. The compositions can be used to treat or prevent one or more bone diseases or disorders of the bone, such as osteoporosis. Alternatively, the particles can be coated onto a substrate, such as the surface of an implant. The coatings can be used to improved biocompatibility of the implant, prevent loosening of the implant, reducing leaching of metal ions from metallic implants, and reduce corrosion. The coatings can be applied to the substrate using a variety of techniques well known in the art. In one embodiment, the coating is applied using electrophoretic deposition. The use of nano- and/or microparticles that provide high surface area helps to improve interfacial strength between the coating and the implant, which allows for the use of lower sintering temperatures. Lowering sintering temperatures minimizes or prevents thermal decomposition of the coating material and/or degradation of the implant material.
Inventor: Lu, Weijia William | Li, Zhaoyang | Lam, Wing Moon Raymond | Luk, Dip Kei Keith
Priority Number: US20080317807A1
IPC Current: A61K000900 | A61K000914 | A61K000920 | A61K000948 | A61K003306 | A61K003342 | A61P001908
US Class: 424422 | 424451 | 424464 | 424489 | 424602 | 424682
Assignee Applicant: The University of Hong Kong
Title: STRONTIUM FORTIFIED CALCIUM NANO-AND MICROPARTICLE COMPOSITIONS AND METHODS OF MAKING AND USING THEREOF
Usefulness: STRONTIUM FORTIFIED CALCIUM NANO-AND MICROPARTICLE COMPOSITIONS AND METHODS OF MAKING AND USING THEREOF
Summary: The pharmaceutical composition is useful as tablets, capsules, caplets, solutions, syrups, and suspensions for treating bone disease or disorder. The bone disease or disorder is osteoporosis (claimed).
Novelty: Pharmaceutical composition for treating bone disease e.g. osteoporosis, has nanoparticles, microparticles comprising strontium-fortified calcium compounds containing calcium ions and strontium ions and anions e.g. phosphate
诊断/治疗
人类免疫缺陷病毒
香港
