Gene therapy of HBV infection via adeno-associated viral vector mediated long term expression of small hairpin RNA (shRNA)
The invention provides a vector comprising an AAV-shRNA vector. The vector is preferably rAAV-151i/1694i. The invention also provides a method of suppressing or inhibiting HBV replication in liver cells infected therewith, comprising administering an amount of an AAVB-shRNA vector effective to suppress, inhibit or reduce HBV replication.
Patent Number: US20070027099A1
Application Number: US2006451876A
Inventor: Lin, Marie | He, Ming Liang | Kung, Hsiang Fu
Priority Date: 19 May 2003
Priority Number: US20070027099A1
Application Date: 12 Jun 2006
Publication Date: 1 Feb 2007
IPC Current: A61K004800
US Class: 514044A | 514044
Title: Gene therapy of HBV infection via adeno-associated viral vector mediated long term expression of small hairpin RNA (shRNA)
Usefulness: Gene therapy of HBV infection via adeno-associated viral vector mediated long term expression of small hairpin RNA (shRNA)
Summary: The nucleic acid molecule is useful in treating a disease related to hepatitis B virus (HBV) or in improving liver function in a subject (claimed).
Novelty: New nucleic acid molecule that hybridizes under stringent conditions to an isolated nucleic acid molecule, useful in treating a disease related to hepatitis B virus (HBV) or in improving liver function in a subject
生物医学
病原
香港
