ANNEXIN II COMPOSITIONS FOR TREATING OR MONITORING INFLAMMATION OR IMMUNE-MEDIATED DISORDERS FIELD OF THE INVENTION
Methods and compositions for treating, detecting, diagnosing or assisting in the diagnosis of an inflammatory or immunological disorder are provided. The authors have made the novel discovery that anti-dsDNA antibodies are reactive to cell surface annexin II and through this interaction, anti-dsDNA antibodies are bound and then internalized and translocated into the cytoplasm and/or nucleus where they mediate altered cellular functions. Compositions that inhibit or interfere with the interaction of annexin II with anti-dsDNA antibodies can be used to treat one or more symptoms or pathological processes of an inflammatory or immunological disorder, preferably an auto-immune disorder. Methods for monitoring the progression or severity of an inflammatory or immunological disorder are also provided. In certain embodiments, levels of annexin II and/or anti-dsDNA antibodies, including anti-dsDNA antibodies that can bind to annexin II, are assessed and compared to a reference level of annexin II and/or anti-dsDNA antibodies that corresponds to a specific stage or severity of the disorder.
Patent Number: US20100098715A1
Application Number: US2009645036A
Inventor: Chan, Daniel Tak Mao | Yung, Susan Sou Ying
Priority Date: 14 Jul 2008
Priority Number: US20100098715A1
Application Date: 22 Dec 2009
Publication Date: 22 Apr 2010
IPC Current: A61K0039395 | A61K00317052 | A61K003802 | A61P002900 | A61P003700 | C12N0015113
US Class: 5140011 | 4241721 | 514044A | 514002
Assignee Applicant: The University of Hong Kong
Title: ANNEXIN II COMPOSITIONS FOR TREATING OR MONITORING INFLAMMATION OR IMMUNE-MEDIATED DISORDERS
Usefulness: ANNEXIN II COMPOSITIONS FOR TREATING OR MONITORING INFLAMMATION OR IMMUNE-MEDIATED DISORDERS
Summary: The method is useful for treating inflammatory or immunological disease or disorder e.g. autoimmune disease, systemic lupus erythematosus, kidney disease or disorder, and lupus nephritis characterized by presence of anti-dsDNA antibodies (all claimed). The inflammatory or immunological disease or disorder includes ankylosing spondylitis, autoimmune hemolytic anemia, autoimmune hepatitis, cardiomyopathy, dermatomyositis, Grave's disease, insulin dependent diabetes, juvenile arthritis, mixed connective tissue disease, multiple sclerosis, myasthenia gravis, pemphigus vulgaris, pernicious anemia, polyarteritis nodosa, psoriasis, rheumatic fever, sarcoidosis, scleroderma, Sjogren's syndrome, ulcerative colitis, uveitis, vasculitis, and vitiligo.
Novelty: Treating inflammatory or immunological disease or disorder e.g. autoimmune disease or vitiligo characterized by presence of anti-double-stranded DNA antibodies, by administering composition comprising ligand for annexin II
生物医学
医药成分
香港
