A NOVEL HUMAN VIRUS CAUSING RESPIRATORY TRACT INFECTION AND USES THEREOF
The present invention provides the complete genomic sequence of a novel human coronavirus, coined as human coronavirus- HKU1 ("HCoV-HKU1"), isolated in Hong Kong. The virus belongs to the order Nidovirales of the family Coronaviridae, being a single-stranded RN virus of positive polarity. Futher study on nasopharyngeal aspirates from patients with community-acquired pnbeumonia has revealed that there are two genotypes, genotype A and genotype B, for this virus. In addition to the genomic sequences of these two genotypes, the invention provides the deduced amino acid sequences of the complete genome of the CoV-HKU1. The nucleotide sequences and deduced amino acid sequences of the HCoV-HKU1are useful in preventing, diagnosing and/or treating the infection by HCoV-HKU1. Furthermore, the invention provides immunogenic and vaccine preparations using recombinant and chimeric forms as well as subunits of the HCoV- HKU1 based on the nucleotide sequences and deduced amino acid sequences of the HCoV-HKU1.
Inventor: YUAN, Guo-yong | CHEN, Guo-xiong | GUAN, Yi | PAN, Lie-wen | Nicholls J M | Peiris J S M | LIANG F C
Priority Number: CN102021147A
IPC Current: C12N000700 | A61P001100 | A61P003114 | C12N001550 | C12Q000170 | C12Q000168 | C12R000193
Assignee Applicant: Versitech Ltd of HKU
Title: A novel human virus causing severe acute respiratory syndrome (sars) and uses thereof | Novel human virus causing severe acute respiratory syndrome (SARS) and application thereof
Usefulness: A novel human virus causing severe acute respiratory syndrome (sars) and uses thereof | Novel human virus causing severe acute respiratory syndrome (SARS) and application thereof
Summary: The hSARS virus, nucleic acids, and polypeptides are useful as vaccines for diagnosing or treating SARS. They are also useful in clinical and scientific research applications.
Novelty: New isolated human severe acute respiratory syndrome (hSARS) virus, useful as vaccine for diagnosing or treating SARS or in clinical and scientific research applications
生物医学
病原
香港
