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Antigenized Antibody Vaccine for Foot-and-Mouth Disease

总结

Antibodies are proteins produced by the body!|s immune system in response to foreign elements (antigens) which invade the body. Antigenized antibodies are antibodies which are genetically engineered in their variable domain to express epitopes of different antigens. As such, antigenized antibodies can be used as an alternative approach to conventional or synthetic peptide vaccination. This new vaccine formulation is an antigenized antibody gene which elicits immunicity against foot-and-mouth disease virus.

The new FMD Vaccine is created by grafting a genetically engineered viral peptide sequence onto swine immunoglobulin(IgM) molecules. When injected into the host, it will stimulate immunogenicity against the complimentary determining regions(CDR) of the FMD virus. It overcame the problem with conventional FMD vaccine using inactive virus, which are proven inefficient and expensive. The fact that the new FMD Vaccines does not contain a viral RNA eliminated potential safety problem with possible not completely inactivated virus in conventional vaccines that can therefore cause the disease to spread.

Foot-and-Mouth Disease(FMD) is a highly contagious, severely debilitating disease which infects all cloven-hoofed animals. It is endemic in many developing countries in Asia, Africa, and parts of South America. To the swine growing business, FMD reduces livestock productivity, incurs high vaccination costs, and restricts the international trade of livestock and products. The economic loss of one pig farm in Hong Kong at the outbreak of FMD can reach HK$2,000,000.

技术优势

1. Low manufacturing cost
2. High production yield
3. High efficacy
4. No live virus involve and so higher safety factor
5. Can be adapted to cope with viral mutation and so wider protection range
6. High quality products using less production time

技术应用

- Foot-And-Mouth Disease Vaccine

附加资料

Patent Number: US6774225B2
Application Number: US1999291299A
Inventor: Yong, Xie
Priority Date: 15 Apr 1999
Priority Number: US6774225B2
Application Date: 15 Apr 1999
Publication Date: 10 Aug 2004
IPC Current: C07K001409 | C07K001600 | A61K003900
US Class: 5360234 | 53602353 | 53602372 | 514044
Assignee Applicant: The Hong Kong University of Science & Technology
Title: Antigenized antibody vaccine for foot-and-mouth disease
Usefulness: Antigenized antibody vaccine for foot-and-mouth disease
Summary: (I) is useful for eliciting immune system response against FMD in swine (claimed).
Novelty: Novel vaccine for foot-and-mouth disease in swine, comprises construct of foot-and-mouth disease virus epitopes of cDNA or their protein counterparts

主要类别

生物医学

细分类别

医药成分

申请日期

15 Apr 1999

申请号码

US 09/291299

专利信息

US 6774225

ID号码

TTC.PA.074

国家/地区

香港