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A Catalogue of Chinese-relevant Genetic Markers for Diabetes

总结

The present invention identifies and describes several genes that may account for at least 14% of young onset diabetes in Chinese. These include novel mutations in the glucokinase and hepatocyte nuclear factor-1  genes, as well as known mutations in the amylin gene and mitochondrial DNA. This catalogue of genetic markers can be used as a diagnostic tool to identify subjects predisposed to diabetes.

072 non-conf abstract 1

附加资料

Inventor: CHAN, JULIANA C N | NG, MAGGIE C Y | COCKRAM, CLIVE S | CRITCHLEY, JULIANA A J H | LEE, SHAO C
Priority Number: CN1496412B
IPC Current: C12Q000168 | C07H002100 | C07K0014435 | C07K001447 | C07K0014575 | C12N000912
Assignee Applicant: The Chinese University of Hong Kong
Title: Method for estimating danger of diabetes typ B developed in the human species of Chinese bloodline and composition | Used for evaluation Chinese ancestry of the race developing 2 diabetes risk method and composition
Usefulness: Method for estimating danger of diabetes typ B developed in the human species of Chinese bloodline and composition | Used for evaluation Chinese ancestry of the race developing 2 diabetes risk method and composition
Summary: The microchip is useful for detecting an increased risk of an individual with decreased insulin secretory function to develop type 2 diabetes, screening for genetic mutations in an individual diagnosed with type 2 diabetes, screening for genetic mutations indicative of increased risk of an individual to develop type 2 diabetes, and screening for a genetic predisposition to develop type 2 diabetes in an individual having a primary family member that has been diagnosed with type 2 diabetes, where the individual is of a Chinese population (claimed).
Novelty: Microchip useful for detecting increased risk of, or predisposition to Type-2 diabetes or screening genetic mutations in Chinese individuals, comprises genes having mutations which indicate a predisposition for type-2 diabetes

主要类别

生物医学

细分类别

DNA /基因工程

申请号码

01/MED/072 Inventor: Professor Chung Ngor Juliana CHAN, Department of Medicine & Therapeutics Patent Status:  Chinese Patent Pending  US Patent Pending  HK Standard Patent Pending

国家/地区

香港