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Hemostatic and Wound Healing Compositions

Technology Benefits: Reduced amount of heat generated by the hemostatic agent Improved blood-clotting efficiency (it is able to stop an arterial hemorrhage) Easy to apply, even in an emergency situation The hemostatic agents can be packaged in a medical gauze, providing a simple and cost effective device

Detailed Technology Description: Researchers at UC Santa Barbara have developed a method to control the amount of heat generated upon application of silaceous oxide to a wound, allowing for the intentional cauterization of traumatic wounds while minimizing heat generation. The peak temperature was reduced from 190°F to 90°F, eliminating the risk of burns. In addition to the dry bound zeolite, UCSB researchers have also developed hemostatic compositions using mesocellular oxide foam. The use of foam permits a rapid initiation of blood clotting, reduces adverse side effects, and allows the release of antibiotics and anti-inflammatory to the wound during the application of the hemostatic agent. The compounds have been approved by FDA for temporary external use to control traumatic bleeding. - UC Case No. 2005-388: “Inorganic Materials for Hemostatic Modulation and Therapeutic Wound Healing” Porous and non-porous inorganic materials to treat traumatically injured tissue through rapid dehydration of a wound with controllable warming of the injured site U.S. Patent Application Nos. 11/398,161; 12/352,513 - UC Case No. 2006-081: “Oxides for Wound Healing and Body Repair” A homogeneous composition of oxide materials prepared to modulate hemostasis and facilitate the blood coagulation, accelerating bone generation and assisting in wound healing and tissue repair. U.S. Patent Application No. 11/464,825 - UC Case No. 2007-313: “Hemostatic Compositions and Methods of Use” Wet layered clays used as hemostatic agent to promote blood clotting. U.S. Patent Application No. 12/030,779 - UC Case No. 2008-196: “Mesocellular Oxide Foams as Hemostatic Compositions and Methods of Use” Mesocellular foams used as hemostatic agents to facilitate clotting, wound healing, and reduce the risk of infection. It can be provided in combination with antibiotics, ions, or anti-inflammatory agents. U.S. Patent Application No. 12/191,257

Supplementary Information: Patent Number: US7858123B2
Application Number: US2006398161A
Inventor: Stucky, Galen D. | Ostomel, Todd A. | Shi, Qihui | Stoimenov, Peter K. | Holden, Patricia A.
Priority Date: 4 Apr 2005
Priority Number: US7858123B2
Application Date: 4 Apr 2006
Publication Date: 28 Dec 2010
IPC Current: A61K000914 | A01N002500 | A01N005900 | A61K003300 | A61K004700 | A61M000100
US Class: 424600 | 424489 | 424617 | 424618 | 514769 | 514770 | 604367
Assignee Applicant: The Regents of the University of California
Title: Inorganic materials for hemostatic modulation and therapeutic wound healing
Usefulness: Inorganic materials for hemostatic modulation and therapeutic wound healing
Summary: (C1) Is useful for modulating hemostasis, or for coating a medical device.
Novelty: Hemostatic modulation composition, useful for treating wounds, comprises silaceous oxide that generates reduced heat of hydration upon contact with blood

Industry: Biomedical

Sub Category: Medical Composition

Application No.: 7858123

Others

Background

Treatment of severely bleeding wounds can require immediate attention to bring the bleeding under control. Severe bleeding poses a very real risk of death to the casualty if not treated quickly. When a laceration or penetrating trauma (e.g., knife or gun wound) is severe enough or involves critical arteries or veins, the bleeding must be slowed immediately or irreversible damage to organs and mortality can result. In recent years, scientists have attempted to reduce blood flow by applying dehydrated zeolite material to the bleeding site in order to induce hemostasis through dehydration of the wounded area and induction of a blood clot formation. The major disadvantage of this technique is the excessive heat generated at the injured site. There is an urgent need to minimize the heat generated by the hemostatic materials upon contact with blood. Of particular interest are such hemostatic compositions that can be rapidly and safely applied in an emergency situation, such as on the battlefield or at the scene of an accident, without the need for intense training or equipment.

Additional Technologies by these Inventors

Tech ID/UC Case

20747/2005-388-0

Related Cases

2005-388-0, 2006-081-2, 2007-313-2, 2008-196-2

*Abstract: A method to control the amount of heat generated upon application of silaceous oxide to a wound, allowing for the intentional cauterization of traumatic wounds while minimizing heat generation.

*IP Issue Date: Dec 28, 2010

*Principal Investigator: Name: Patricia Ann Holden
Department:

Name: Todd Ostomel
Department:

Name: Qihui Shi
Department:

Name: Peter Stoimenov
Department:

Name: Galen Stucky
Department:

Country/Region: USA

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